The clash is vital to the state of affairs at the top of the table, with Liverpool keen on having an edge over Manchester City for the top spot. United, meanwhile, will be looking to survive in the top four, with Ole Gunnar Solskjaer intent on keeping his unbeaten streak in the Premier League intact.
Let us have a look at how the two teams may lineup:
Anthony Martial and Jesse Lingard were the visible absentees from the FA Cup win against Chelsea, having missed out due to the knocks they received against PSG. However, Solskjaer was positive about his update on the duo and they seem certain to play a part in the game.
Elsewhere, Darmian and Valencia still remain out, with Rojo potentially in the final stages of making a complete recovery.
The heroics of Pogba, Herrera, and Rashford will be crucial for the Red Devils to bag all three points.
Goalkeeper: De Gea
Defenders: Young, Bailly, Lindelof, Shaw
Midfielders: Herrera, Matic
Forwards: Lingard, Pogba, Martial; Rashford
WATCH: What Will Happen If United Win vs. Liverpool
Jurgen Klopp’s side will see the return of Virgil Van Dijk to the starting lineup. Further, defender Dejan Lovren will remain sidelined for the encounter with a hamstring problem, while Xherdan Shaqiri may have a chance of putting in a few minutes after returning from injury.
The likes of Oxlade-Chamberlain and Joe Gomez, however, remain long term absentees, although the former has a quicker scope of coming back to training.
Klopp has mentioned that even a single point taken will be a big deal for the side. The match is bound to have more than just that on show.
Defenders: Alexander-Arnold, Matip, Van Dijk, Robertson
Midfielders: Wijnaldum, Henderson, Fabinho
Forwards: Salah, Firmino, Mane